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Publikationen P.Fischer & Arbeitsgruppe

by P. Bebié, R. Becker, V. Commichau, J. Debus, G. Dissertori, L. Djambazov, A. Eleftheriou, J. Fischer, P. Fischer, M. Ito, P. Khateri, W. Lustermann, C. Ritzer, M. Ritzert, U. Röser, C. Tsoumpas, G. Warnock, B. Weber, M. T. Wyss and A. Zagozdzinska-Bochenek
Abstract:
(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2mm and an inner diameter of 114mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between separate-uncertainty 209.0(3)ps and separate-uncertainty 12.41(02) Full Width at Half Maximum (FWHM) at low activity and separate-uncertainty 326.89(12)ps and separate-uncertainty 20.630(011) FWHM at 550MBq, respectively. The peak sensitivity is ∼1.6. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500MBq.
Reference:
SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI (P. Bebié, R. Becker, V. Commichau, J. Debus, G. Dissertori, L. Djambazov, A. Eleftheriou, J. Fischer, P. Fischer, M. Ito, P. Khateri, W. Lustermann, C. Ritzer, M. Ritzert, U. Röser, C. Tsoumpas, G. Warnock, B. Weber, M. T. Wyss and A. Zagozdzinska-Bochenek), In Sensors, volume 21, 2021.
Bibtex Entry:
@Article{s21217037,
  author =       "Pascal Bebié and Robert Becker and Volker Commichau
                 and Jan Debus and Günther Dissertori and Lubomir
                 Djambazov and Afroditi Eleftheriou and Jannis Fischer
                 and Peter Fischer and Mikiko Ito and Parisa Khateri and
                 Werner Lustermann and Christian Ritzer and Michael
                 Ritzert and Ulf Röser and Charalampos Tsoumpas and
                 Geoffrey Warnock and Bruno Weber and Matthias T. Wyss
                 and Agnieszka Zagozdzinska-Bochenek",
  title =        "{SAFIR}-{I}: Design and Performance of a High-Rate
                 Preclinical {PET} Insert for {MRI}",
  journal =      "Sensors",
  volume =       "21",
  year =         "2021",
  number =       "21",
  article-number = "7037",
  pubmedid =     "34770344",
  ISSN =         "1424-8220",
  abstract =     "(1) Background: Small Animal Fast Insert for MRI
                 detector I (SAFIR-I) is a preclinical Positron Emission
                 Tomography (PET) insert for the Bruker BioSpec 70/30
                 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic
                 Resonance Imaging (MRI) system. It is designed
                 explicitly for high-rate kinetic studies in mice and
                 rats with injected activities reaching 500MBq, enabling
                 truly simultaneous quantitative PET and Magnetic
                 Resonance (MR) imaging with time frames of a few
                 seconds in length. (2) Methods: SAFIR-I has an axial
                 field of view of 54.2mm and an inner diameter of 114mm.
                 It employs Lutetium Yttrium OxyorthoSilicate (LYSO)
                 crystals and Multi Pixel Photon Counter (MPPC) arrays.
                 The Position-Energy-Timing Application Specific
                 Integrated Circuit, version 6, Single Ended (PETA6SE)
                 digitizes the MPPC signals and provides time stamps and
                 energy information. (3) Results: SAFIR-I is
                 MR-compatible. The system’s Coincidence Resolving
                 Time (CRT) and energy resolution are between
                 separate-uncertainty 209.0(3)ps and
                 separate-uncertainty 12.41(02) Full Width at Half
                 Maximum (FWHM) at low activity and separate-uncertainty
                 326.89(12)ps and separate-uncertainty 20.630(011) FWHM
                 at 550MBq, respectively. The peak sensitivity is
                 ∼1.6. The excellent performance facilitated the
                 successful execution of first in vivo rat studies
                 beyond 300MBq. Based on features visible in the
                 acquired images, we estimate the spatial resolution to
                 be ∼2mm in the center of the Field Of View (FOV). (4)
                 Conclusion: The SAFIR-I PET insert provides excellent
                 performance, permitting simultaneous in vivo small
                 animal PET/MR image acquisitions with time frames of a
                 few seconds in length at activities of up to 500MBq.",
  doi =          "10.3390/s21217037",
}

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